Tubastatin A hydrochloride

Aliases: Tubastatin A, N-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide, hydrochloride
Catalog No: 14084 Format: 25 mg $395 Buy
Catalog No: 14085 Format: 5 mg $110 Buy
Application: Histone Acetylation (HAT & HDAC)

Chemical Properties

MW = 371.9
C20H21N3O2• HCl
CAS 1310693-92-5
99% (HPLC); NMR (Conforms)

Description

Potent and selective histone deacetylase 6 (HDAC 6) inhibitor (IC50 = 15 nm; >1000-fold selective against other HDACs and 60-fold for HDAC8))(ref 1). Inhibits TNFα (IC50 = 272 nm) and IL-6 (IC50 = 712 nm) in LPS-stimulated human macrophages and displays anti-inflammatory activity in animal models (ref 2). Improves survival in animal models of sepsis (ref 3). Improves cognition in Alzheimers disease transgenic mice (ref 4). Cell permeable.

Contents

White powder. May be dissolved in DMSO (50 mg/ml).

Storage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.

References

1. KV Butler et al. J. Am. Chem. Soc. 2010, 132:10842
2. S Vishwakarma et al. Int. Immunopharmacol. 2013, 16:72
3. T Zhao et al. Surg. Res. 2014, 190:647
4. L Zhang et al. J. Alzheimers Dis. 2014, 41:1193

 
Chemical structure of Tubastatin A hydrochloride.

Chemical structure of Tubastatin A hydrochloride.