CI-994

Aliases: N-acetyl-dinaline; 4-(Acetylamino)-N-(2-aminophenyl)benzamide; PD-123654
Catalog No: 14092 Format: 25 mg $295 Buy
Catalog No: 14093 Format: 5 mg $85 Buy

Application: Histone Acetylation (HAT & HDAC)

Chemical Properties

MW = 269.3
C15H15N3O2
CAS 112522-64-2
>98% (TLC); NMR (Conforms)

Description

Orally active histone deacetylase (HDAC) inhibitor (IC50 = 0.9, 0.9, 1.2, and >20 µM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively) (ref1). Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo (ref 2,3). Increase neuroplasticity during memory extinction (ref 4). Protects beta cells from cytokine-induced apoptosis (ref 4).

Contents

Off-white powder. May be dissolved in DMSO (25 mg/ml).

Storage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.

References

1. OM Moradei et al. J. Med. Chem. 2007, 50:5543
2. T Beckers et al. Int. J. Cancer 2007, 121:1138
3. M Loprevite et al. Oncol. Res. 2005, 15:39
4. DH Chou et al. Chem. Biol. 2012, 19:669

 

Chemical structure of CI-994.