CPTH2

Aliases: Cyclopentylidene-[4-(4’-chlorophenyl)thiazol-2-yl]hydrazone
Catalog No: 14094 Format: 25 mg $290 Buy
Catalog No: 14095 Format: 5 mg $85 Buy
Application: Histone Acetylation (HAT & HDAC)

Chemical Properties

MW = 291.8
C14H14ClN3S
CAS 357649-93-5
>98% (TLC); NMR (Conforms)

Description

CPTH2 is a selective inhibitor of the histone acetyltransferase Gcn5P both in vitro and in vivo (IC50 = 0.8 M) (ref1). In vitro the HAT inhibitory activity of CPTH2 was caused via bridge-interaction with histone H3. In vivo it decreased acetylation of bulk histone H3 at the H3K14ac site.

Contents

White powder. May be dissolved in DMSO (>25 mg/ml).

Storage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.

References

1. F Chimenti et al. J. Med. Chem. 2009, 52:530

 
Chemical structure of CPTH2.

Chemical structure of CPTH2.