|Aliases: 2'-Deoxy-5-fluorocytidine, 5-Fluoro-2'-deoxycytidine; FCDR; FdCyd; NSC-48006|
|Catalog No: 14108||Format: 250 mg||$380||Buy|
|Catalog No: 14109||Format: 50 mg||$95||Buy|
|Application: DNA Methylation|
MW = 245.2
MP = 196°C >98% (TLC); NMR (Conforms)
A DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors (ref 1). Like 5-Azacytidine and decitabine, 2'-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation (ref 2). It blocks proliferation in colon cancer-derived HCT-116 cells by activating DNA response pathways (ref 3). It inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo (ref 4).
White solid. May be dissolved in DMSO (20 mg/ml).
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.
1. J Ren et al. Cell Signal. 2011, 23:1082
2. H Gowher et al. Cancer Biol. Ther. 2004, 3:1062
3. Q Zhao et al. Springerplus 2002, 1:65
4. Y Kumaki et al. Antiviral Res. 2011, 92:329