Aliases: AS-8351, 2-Hydroxy-1-naphthylaldehyde isonicotinoylhydrazone; NSC-5135
Catalog No: 14112 Format: 25 mg $205 Buy
Catalog No: 14113 Format: 5 mg $60 Buy

Application: Histone Methylation (HMT & HDM)

Chemical Properties

MW = 291.3
CAS 796-42-9
MP = 262-264°C
>98% (TLC); NMR (Conforms)


AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts (ref 1). It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351 (ref 1).


Yellow powder. May be dissolved in DMSO (45 mg/ml); Ethanol (10 mg/ml, warm); or DMF (30 mg/ml).

Storage Conditions

Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 1 month.


1. N Cao et al. Science 2016, 352:1216


Chemical structure of AS-8351.