Aliases: Salermide, N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methylbenzeneacetamide
Catalog No: 14124 Format: 25 mg $160 Buy
Catalog No: 14125 Format: 5 mg $50 Buy

Application: Sirtuins

Chemical Properties

MW = 394.5
CAS 1105698-15-4
MP = 175-177°C
>98% (TLC); NMR (Conforms)


SIRT1 and SIRT2 inhibitor. Exhibits a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro. Induces the reactivation of proapoptotic genes repressed by SIRT1 and causes massive apoptosis in cancer cells within 24 hours (ref 1). Displays protective effect in nematodes expressing muscular dystrophy protein (ref 2). Promotes neuronal apoptosis confirming the protective effect of SIRT1 (ref 3).


Yellow powder. May be dissolved in DMSO (40 mg/ml); ethanol (10 mg/ml; warm); or DMF (30 mg/ml).

Storage Conditions

Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 1 month.


1. E Lara et al. Oncogene 2009, 28:781
2. MY Pasco et al. J. Med. Chem. 2010, 53:1407
3. Y Zhao et al. Exp. Neurol. 2012, 237:489


Chemical structure of Salermide.