|Aliases: Mithramycin A, A 2371, Antibiotic LA 7017, Aureolic Acid, NSC 24559, PA 144, Plicamycin|
|Catalog No: 14128||Format: 5 mg||$150||Buy|
|Catalog No: 14129||Format: 1 mg||$45||Buy|
|Application: DNA Methylation|
MW = 1085.2
MP = 177°C >98% (HPLC); NMR (Conforms)
Inhibits DNA methyltransferase (ref 1). A selective Sp1 inhibitor, it binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, inhibiting their expression (ref 2). Mithramycin A (at 10-200 nM) sensitizes tumor cells to TRAIL-induced apoptosis (ref 3).
Yellow powder. May be dissolved in DMSO (20 mg/ml); or ethanol (10 mg/ml).
Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 1 month.
1. RK Lin et al. Anticancer Drugs 2007, 18:157
2. Z Jia et al. Cancer Res. 2010, 70:1111
3. T-J Lee et al. Mol. Cancer Ther. 2006, 5:2737