Mithramycin A

Aliases: Mithramycin A, A 2371, Antibiotic LA 7017, Aureolic Acid, NSC 24559, PA 144, Plicamycin
Catalog No: 14128 Format: 5 mg $160 Buy
Catalog No: 14129 Format: 1 mg $40 Buy
Application: DNA Methylation

Chemical Properties

MW = 1085.2
CAS 18378-89-7
MP = 177°C
>98% (HPLC); NMR (Conforms)


Inhibits DNA methyltransferase (ref 1). A selective Sp1 inhibitor, it binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, inhibiting their expression (ref 2). Mithramycin A (at 10-200 nM) sensitizes tumor cells to TRAIL-induced apoptosis (ref 3).


Yellow powder. May be dissolved in DMSO (20 mg/ml); or ethanol (10 mg/ml).

Storage Conditions

Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 1 month.


1. RK Lin et al. Anticancer Drugs 2007, 18:157
2. Z Jia et al. Cancer Res. 2010, 70:1111
3. T-J Lee et al. Mol. Cancer Ther. 2006, 5:2737

Chemical structure of Mithramycin A.

Chemical structure of Mithramycin A.