Recombinant HDAC7 protein
|Aliases: HD7; HD7A; HDAC7A|
|Catalog No: 31352||Format: 10 µg||Discontinued|
Expressed In: Baculovirus Protein Species: Human
A representative Technical Data Sheet (TDS) is provided here. Please refer to the lot-specific TDS you will receive with your order for the lot-specific buffer contents and protein concentration.
HDAC7 (Histone Deacetylase 7) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).
Recombinant HDAC7 is suitable for use in histone deacetylase (HDAC) assays. It can also be used to study enzyme kinetics, inhibitor screening, and selectivity profiling.
Specific Activity: 17,824 pmol/min/μg.
The C-terminal part of HDAC7 (accession number AY302468) including the catalytic domain (amino acids 518-end) was expressed with an N-terminal GST-Tag (MW = 78 kDa) in a baculovirus expression system.
Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
This product is guaranteed for 6 months from date of receipt.
This product is for research use only and is not for use in diagnostic procedures.