PXR antibody (pAb)

Aliases: Nuclear Receptor Subfamily 1 Group I Member 2, Orphan Nuclear Receptor PXR, Pregnane X Receptor, Orphan Nuclear Receptor PAR1
Catalog No: 39589 Format: 200 µl $435 Buy
Catalog No: 39590 Format: 10 µl $105 Buy

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Antibody Type:
Affinity Purified
Molecular Weight:
54 kDa


Western Blot Validated

Application Notes

Validated Applications:
WB: 1:500 - 1:2,000 dilution


This PXR antibody was raised against a peptide containing amino acid residues 57-71 of human PXR.


Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.


PXR antibody (pAb) tested by Western blot.

PXR pAb tested by Western blot.
Hep G2 nuclear extract (20 µg per lane) was probed with PXR pAb at a dilution of 1:1,000.


PXR (NR1I2, Pregnane X receptor, nuclear receptor subfamily 1 group I member 2) belongs to a family of transcription factors characterized by a ligand-binding domain and a DNA-binding domain. PXR is an orphan receptor that regulates transcription of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR (RXR-α and RXR-β). PXR is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin.

Positive Control

Active Motif's Hep G2 nuclear extract (Catalog No. 36011) can be used as a positive control for PXR antibody.


Some products may be shipped at room temperature. This will not affect their stability or performance. Upon receipt, unconjugated antibodies may be stored at -20°C for up to 2 years. Fluorophore- & enzyme-conjugated antibodies should be stored at 4°C. Fluorophore-conjugated antibodies should be protected from light. Keep reagents on ice when not in storage; to avoid repeated freeze/thaw cycles, we recommend aliquoting items that will be stored frozen into single-use fractions prior to freezing.


This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.

Application Key

  • ChIP = Chromatin Immunoprecipitation;
  • DB = Dot Blot;
  • ELISA = Enzyme-linked Immunosorbent Assay;
  • EMSA = Electrophoretic Mobility Shift Assay
  • FC = Flow Cytometry;
  • ICC = Immunocytochemistry;
  • IF = Immunofluorescence;
  • IHC = Immunohistochemistry;
  • IP = Immunoprecipitation;
  • MeDIP = Methyl-DNA Immunoprecipitation;
  • TR-FRET = Time-Resolved Fluorescence Resonance Energy Transfer;
  • WB = Western Blotting