Recombinant Histone H2A/H2B dimer

Catalog No: 81167 Format: 100 µg $450 Buy
Catalog No: 81867 Format: 1 mg $3,000 Buy

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Expressed In: E. coli Protein Species: Human


A representative Technical Data Sheet (TDS) is provided here. Please refer to the lot-specific TDS you will receive with your order for the lot-specific buffer contents and protein concentration.


Histone H2A and H2B are the core components of the nucleosome. H2A and H2B assemble H2A/H2B dimer, and two H2A/H2B dimers combine with H3/K4 tetramer to form histone octamer. The histone octamer is wrapped around by 146 bp DNA to assemble a nucleosome, which is the basic structural unit of chromatin in vivo.

Application Notes

Recombinant Histone H2A/H2B Dimer is suitable for use as substrates in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.

Protein Details

Recombinant histone H2A/H2B Dimer consists of full length human histones H2A (accession number NP_003503.1) and full length human histone H2B (accession number NP_003509.1). Histone H2A and H2B were expressed in E. coli cells. Recombinant Histone H2A/H2B Dimer was assembled by dialysis and purified by gel filtration. The molecular weight of the Histone H2A/H2B Dimer is 27.9 kDa.


Recombinant Histone H2A/H2B Dimer
13% SDS-PAGE Coomassie staining

H2A: 14.1 kDa
H2B: 13.8 kDa

Purity: ≥ 90%


Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.


This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.