Recombinant CDKN2B protein

Aliases: Cyclin dependent kinase Inhibitor 2B, MTS2, INK4B, CDK4I, TP15, P15, P15 CDK Inhibitor
Catalog No: 81448 Format: 50 µg $470 Add to Cart
Catalog No: 81548 Format: 1 mg $2,950 Add to Cart

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Expressed In: E. coli Protein Species: Human

Contents

A representative Technical Data Sheet (TDS) is provided here. Please refer to the lot-specific TDS you will receive with your order for the lot-specific buffer contents and protein concentration.

Background

CDKN2B(Cyclin-dependent kinase 4 inhibitor B,This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclindependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Application Notes

This product was manufactured as described in Protein Details. Where possible, Active Motif has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data for a given product is shown on the lot-specific Technical Data Sheet.

Protein Details

Recombinant CDKN2B protein that includes full length of human CDKN2B protein (accession number NP_004927.2) was expressed was expressed in E. coli cells with an N-terminal GST tag. The molecular weight of the protein is 41.55 kDa.

References

Human

 
Recombinant CDKN2B protein

Recombinant CDKN2B protein

12.5% SDS-PAGE Coomassie staining

MW: 41.55 kDa

Purity: ≥ 85%

Storage

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Guarantee

This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.