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Recombinant RHEB protein
| Aliases: GTP-binding protein Rheb, RHEB2, Ras Homolog Enriched In Brain 2 |
| Catalog No: 81480 | Format: 100 µg | $480 | Add to Cart |
| Catalog No: 81580 | Format: 1 mg | $2,950 | Add to Cart |
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Expressed In: E. coli Protein Species: Human
Contents
A representative Technical Data Sheet (TDS) is provided here. Please refer to the lot-specific TDS you will receive with your order for the lot-specific buffer contents and protein concentration.
Background
RHEB (GTP-binding protein Rheb) is a is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in the regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.
Application Notes
This product was manufactured as described in Protein Details. Where possible, Active Motif has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data for a given product is shown on the lot-specific Technical Data Sheet.
Protein Details
Recombinant RHEB protein that includes full length of the human RHEB protein (accession number NP_005605.1) was expressed in E.coli cells with an C-terminal His tag, The molecular weight of the protein is 21.56 kDa.
References
Human
Recombinant RHEB protein
12.5% SDS-PAGE gel stained with Coomassie Blue.
MW: 21.56 kDa
Purity: >90%
Storage
Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Guarantee
This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.
