Cart
Products
Recombinant HER4 / ErbB4 (682-993) protein
| Catalog No: 81356 | Format: 20 µg | $480 | Add to Cart |
| Catalog No: 81756 | Format: 1 mg | $4,150 | Add to Cart |
Request a quote for a bulk order Request Quote
Expressed In: Baculovirus Protein Species: Human
Contents
A representative Technical Data Sheet (TDS) is provided here. Please refer to the lot-specific TDS you will receive with your order for the lot-specific buffer contents and protein concentration.
Background
HER4, also known as ErbB4 (Erb-B2 Receptor Tyrosine Kinase 4) is a tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. It is required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation and is required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. It is also necessary for mammary gland differentiation, induction of milk proteins and lactation. HER4 acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF and mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Mutations in HER4 have been identified in various cancer types including melanoma, lung adenocarcinoma and medulloblastoma.
Application Notes
This product was manufactured as described in Protein Details. Where possible, Active Motif has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data this product is shown.
Protein Details
Recombinant HER4 / ErbB4 (682-993) protein that includes amino acids 682-993 of human HER4 protein (accession number NP_005226.1) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 36.6 kDa.
References
Human
Recombinant HER4 / ErbB4 (682-993) protein
10% SDS-PAGE with Coomassie staining
MW: 36.6 kDa
Purity: >90%
Storage
Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Guarantee
This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.
