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Recombinant NFATC3 protein
| Aliases: Nuclear Factor of Activated T Cells 3, NFAT4, N339260, NFATX, Calcineurin-Dependent 3, NF-AT4c |
| Catalog No: 82097 | Format: 20 µg | $480 | Add to Cart |
| Catalog No: 82697 | Format: 1 mg | $5,400 | Add to Cart |
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Expressed In: Baculovirus Protein Species: Human
Contents
A representative Technical Data Sheet (TDS) is provided here. Please refer to the lot-specific TDS you will receive with your order for the lot-specific buffer contents and protein concentration.
Background
NFATC3 acts as a transcriptional activation regulator. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription. Binding to the TNFSF11 promoter region is increased by high levels of Ca2+ which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts. Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling. Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alphabeta E4 promoter region of CRYAB and activates transcription in cardiomyocytes. In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.
Application Notes
This product was manufactured as described in Protein Details. Where possible, Active Motif has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data for this product is shown.
Protein Details
Recombinant NFATC3 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_775188.1) with an N-terminal FLAG tag. The molecular weight of NFATC3 is 116.86 kDa.
Recombinant NFATC3 protein
7.5% SDS-PAGE Coomassie staining
MW:116.86 kDa
Purity: ≥ 95%
Storage
Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Guarantee
This product is guaranteed for 6 months from date of receipt.
This product is for research use only and is not for use in diagnostic procedures.
