Recombinant DDX3X protein

Aliases: ATP-dependent RNA helicase DDX3X, DEAD-Box Helicase, DDX3X, DDX3, HLP2
Catalog No: 82141 Format: 10 µg $415 Add to Cart

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Expressed In: Baculovirus Protein Species: Human

Contents

A representative Technical Data Sheet (TDS) is provided here. Please refer to the lot-specific TDS you will receive with your order for the lot-specific buffer contents and protein concentration.

Background

DDX3X (ATP-dependent RNA helicase DDX3X) is a multifunctional ATP-dependent RNA helicase belonging to the DEAD-box protein family, which is critically involved in numerous aspects of RNA metabolism. Its primary function is to unwind RNA secondary structures, an essential activity that facilitates key processes including transcription, mRNA splicing, nuclear export, translation initiation, and the assembly of stress granules. Furthermore, DDX3X plays vital roles in innate immune signaling pathways by modulating the activity of key kinases and interferon responses. Due to its central role in gene expression and cell growth, mutations in the DDX3X gene are linked to neurodevelopmental disorders and various cancers, highlighting its importance in cellular homeostasis and disease.

Application Notes

This product was manufactured as described in Protein Details. Where possible, Active Motif has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data for a given product is shown on the lot-specific Technical Data Sheet.

Protein Details

Recombinant DDX3X protein was expressed in a baculovirus expression system as the full length protein (accession number NP_001347.3) with an N-terminal FLAG tag. The molecular weight of DDX3X is 74.51 kDa.

References

Human

 
DDX3X Coomassie gel

Recombinant DDX3X protein gel.
DDX3X protein was run on an 4-20% SDS-PAGE gel and stained with Coomassie blue.

MW: 74.51 kDa

Purity: > 90%

Storage

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Guarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.