Recombinant NR1D2 protein

Aliases: Nuclear Receptor Subfamily 1 Group D Member 2
Catalog No: 82158 Format: 20 µg $480 Add to Cart
Catalog No: 82758 Format: 1 mg $4,150 Add to Cart

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Applications

Application Notes

This product was manufactured as described in Protein Details. Where possible, Active Motif has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product.  All available data for this product is shown. 

References

Human

 
Recombinant NR1D2 protein gel

Recombinant NR1D2 protein gel
4-20% SDS-PAGE gel
MW: 65.91 kDa
Purity: >95%

Background

NR1D2 (Nuclear Receptor Subfamily 1 Group D Member 2), also known as Rev-Erbβ, is a transcriptional repressor and a core component of the circadian clock machinery. It functions as a heme-binding nuclear receptor to rhythmically repress the expression of key clock genes, such as BMAL1 (ARNTL), thereby regulating circadian physiology. Beyond timekeeping, NR1D2 integrates metabolic and inflammatory pathways, influencing lipid and glucose homeostasis, as well as macrophage function. Dysregulation of NR1D2 is linked to circadian rhythm disorders, metabolic diseases, and inflammatory conditions.

Storage

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Guarantee

This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.

Application Key

  • ChIP = Chromatin Immunoprecipitation;
  • ChIP = ChIP Sequencing;
  • CUT&RUN = Cleavage Under Targets and Release Using Nuclease;
  • CUT&Tag = Cleavage Under Targets and Tagmentation;
  • DB = Dot Blot;
  • ELISA = Enzyme-linked Immunosorbent Assay;
  • EMSA = Electrophoretic Mobility Shift Assay
  • FC = Flow Cytometry;
  • ICC = Immunocytochemistry;
  • IF = Immunofluorescence;
  • IHC = Immunohistochemistry;
  • IP = Immunoprecipitation;
  • MeDIP = Methyl-DNA Immunoprecipitation;
  • NEU = Neutralizing;
  • TIP-ChIP = Tagmented, Indexed, and Pooled Chromatin Immunoprecipitation;
  • WB = Western Blotting