Recombinant PRDM5 protein

Aliases: BCS2, PFM2
Catalog No: 31494 Format: 20 µg $410 Buy
Expressed In: Baculovirus Protein Species: Human

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Full length recombinant PRDM5 protein was expressed in Sf9 cells and is supplied in 25 mM Hepes pH 7.5, 400 mM NaCl, 5% Glycerol, 0.04% Triton X-100, 0.2 mM TCEP. Please refer to product insert upon arrival for lot-specific concentration.


PRDM5 (PR Domain Containing 5) is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Mutations of PRDM5 causes Type 2 brittle cornea syndrome (BCS2) which is an inherited connective tissue disease with a devastating ocular phenotype through histone and DNA methylation. PRDM5 is a relevant tumour suppressor gene that is frequently targeted in colorectal tumourigenesis. Promoter methylation-mediated downregulation of PRDM5 contributes to the development of lung squamous cell carcinoma. It is a sequence-specific DNA-binding transcription factor and represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.

Application Notes

This product was manufactured as described in Protein Details. Where possible, Active Motif has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data for a given product is shown on the lot-specific Technical Data Sheet.

Protein Details

Recombinant PRDM5 protein (accession number NP_061169.2) was expressed in Sf9 cells and contains an N-terminal FLAG-Tag with a molecular weight of 73.1 kDa. The recombinant protein is >85% pure by SDS-PAGE.

PRDM5 protein Coomassie gel

Recombinant PRDM5 protein gel
PRDM5 protein was run on an 8% SDS-PAGE gel and stained with Coomassie blue.


Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.


This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.