Recombinant Histone H1
|Catalog No: 81126||Format: 100 µg||$110||Buy|
|Catalog No: 81826||Format: 1 mg||$480||Buy|
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Expressed In: E. coli Protein Species: Human
A representative Technical Data Sheet (TDS) is provided here. Please refer to your lot-specific TDS upon arrival for specific buffer contents and lot-specific protein concentration.
Histone H1, also called as H1F0 (H1 Histone Family Member 0), is a replacement subtype, and replicationindependent histone, which is a member of the histone H1 family. It involves in basal repression of gene expression. H1 can act as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Diseases associated with H1F0 include Retinal Cancer and Deafness, Autosomal Dominant.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker- histone H1, with the DNA between the nucleosomes to form higher order chromatin structures. Histone H1 present at the interface between the nucleosome core and DNA entry/exit points.
Recombinant Histone H1 is suitable for use as substrates in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
Full length Histone H1 (accession number NP_005309.1) was expressed in E. coli cells with no tag. The molecular weight of Histone H1 is 21 kDa.
Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.