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Recombinant DHX15 protein
| Aliases: ATP-dependent RNA helicase DHX15, DBP1, HRH2 |
| Catalog No: 82143 | Format: 20 µg | $505 | Add to Cart |
| Catalog No: 82743 | Format: 1 mg | $4,500 | Add to Cart |
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Expressed In: Baculovirus Protein Species: Human
Contents
A representative Technical Data Sheet (TDS) is provided here. Please refer to the lot-specific TDS you will receive with your order for the lot-specific buffer contents and protein concentration.
Background
DHX15 (ATP-dependent RNA helicase DHX15) is a multifunctional DEAH-box RNA helicase involved in several critical steps of RNA metabolism. It plays an essential role in pre-mRNA splicing as a core component of the spliceosome, where it is responsible for catalyzing the release of the lariat intron after splicing catalysis, a key step in spliceosome disassembly. Beyond splicing, DHX15 is a crucial cytoplasmic sensor for viral RNA, initiating innate immune defense pathways by activating NF-κB and MAPK signaling to induce pro-inflammatory cytokines and type I interferons. Its additional functions in ribosomal RNA processing and nonsense-mediated mRNA decay further highlight its importance in maintaining mRNA fidelity and overall cellular homeostasis.
Application Notes
This product was manufactured as described in Protein Details. Where possible, Active Motif has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data for this product is shown.
Protein Details
Recombinant DHX15 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_001349.2) with an N-terminal FLAG tag. The molecular weight of DHX15 is 92.2 kDa.
Recombinant DHX15 protein gel
4-20% SDS-PAGE gel
MW:92.2 kDa
Purity: >95%
Storage
Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Guarantee
This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.
