Recombinant RIGI protein

Aliases: Antiviral innate immune response receptor RIG-1, DEAD Box Polypeptide 58
Catalog No: 82147 Format: 20 µg $470 Add to Cart
Catalog No: 82747 Format: 1 mg $4,150 Add to Cart

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Applications

Application Notes

This product was manufactured as described in Protein Details. Where possible, Active Motif has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product.  All available data for this product is shown. 

References

Human

 
Recombinant RIGI protein gel

Recombinant RIGI protein gel
4-20% SDS-PAGE gel
MW: 107.87 kDa
Purity: >95%

Background

RIGI (Antiviral innate immune response receptor RIG-I) is a crucial cytosolic pattern recognition receptor (PRR) that acts as a primary sensor of viral RNA in the innate immune system. It specifically recognizes short double stranded RNA (dsRNA) and single-stranded RNA with 5’-triphosphate (5’-ppp RNA) ends, which are characteristic of many viral genomes. Upon ligand binding, RIG-I undergoes a conformational change and activates the mitochondrial antiviral-signaling (MAVS) protein, triggering a downstream signaling cascade that leads to the robust production of type I interferons (IFN-α/β) and pro-inflammatory cytokines. This response is essential for establishing an antiviral state in infected and neighboring cells. Dysregulation of RIG-I signaling is associated with autoimmune disorders, chronic inflammation, and inadequate responses to viral infections.

Storage

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Guarantee

This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.

Application Key

  • ChIP = Chromatin Immunoprecipitation;
  • ChIP = ChIP Sequencing;
  • CUT&RUN = Cleavage Under Targets and Release Using Nuclease;
  • CUT&Tag = Cleavage Under Targets and Tagmentation;
  • DB = Dot Blot;
  • ELISA = Enzyme-linked Immunosorbent Assay;
  • EMSA = Electrophoretic Mobility Shift Assay
  • FC = Flow Cytometry;
  • ICC = Immunocytochemistry;
  • IF = Immunofluorescence;
  • IHC = Immunohistochemistry;
  • IP = Immunoprecipitation;
  • MeDIP = Methyl-DNA Immunoprecipitation;
  • NEU = Neutralizing;
  • TIP-ChIP = Tagmented, Indexed, and Pooled Chromatin Immunoprecipitation;
  • WB = Western Blotting