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Tools to analyze nuclear function,
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Recombinant Proteins & Enzymes

Recombinant Nucleosomes

custom designed recombinant nucleosomes

ReNucs™ are Recombinant Nucleosomes designed to contain specific histone post-translational modifications, amino acid substitutions and other modifications, delivering the most biologically relevant and powerful tools for development of novel drug targets and precision medicine. Developed in our own labs, each recombinant nucleosome is comprised of octamers of designer-modified core histone proteins (H2A, H2B, H3 and H4) bound by DNA. Active Motif currently offers the widest portfolio of pre-assembled Mononucleosome and Polynucleosome proteins available – and as the Epigenetics Experts, we continue to release newly designed ReNucs every month.

All of our recombinant nucleosomes are available in small scale and bulk quantities.

Request a quote for a bulk orderBulk Order Button

 



View our flyer, for a complete listing of Recombinant Nucleosomes,
Mononucleosomes, Polynucleosomes, and related proteins.

HMT activity assay comparing recombinant nucleosomes and histone octamers as substrates.
HMT activity assay comparing recombinant nucleosomes and histone octamers as substrates (click image to enlarge).
 

Whatever your application, ReNucs™ recombinant nucleosome proteins offer the most biologically relevant substrates when compared to histone proteins alone or synthetic peptides:

  1. Mononucleosomes and Polynucleosomes available
  2. Biotinylated nucleosomes for protein-nucleosome interaction studies and pull-down assays
  3. Post-translational modifications – designed for optimal physiological relevance
  4. Amino acid mutations – as published, these ReNucs mostly closely mimic naturally occurring nucleosomes in your own experimental design.
  5. Coming Soon – Quadra-modified ReNucs, including four post-translational modifications in each nucleosome
 
Name Expressed In Format Cat No. Price  
Recombinant Histone Octamer (H3.1) E. coli 100 µg 31470 $410 Buy Now
1 mg 31870 $3,200 Buy Now
Recombinant Histone Octamer (H3.1) - biotinylated E. coli 50 µg 31471 $475 Buy Now
1 mg 31871 $3,500 Buy Now
Recombinant Histone Octamer (H3.3) E. coli 100 µg 31472 $410 Buy Now
1 mg 31872 $3,200 Buy Now
Recombinant Histone Octamer (H3.3) - biotinylated E. coli 50 µg 31473 $475 Buy Now
1 mg 31773 $3,500 Buy Now
Recombinant Mononucleosomes (H2A.Bbd) - biotinylated E. coli 20 µg 31556 $435 Buy Now
Recombinant Mononucleosomes (H2A.X) E. coli 20 µg 81125 $400 Buy Now
1 mg 81825 $4,450 Buy Now
Recombinant Mononucleosomes (H2A.X) - biotinylated E. coli 20 µg 31582 $435 Buy Now
Recombinant Mononucleosomes (H2A.Z) E. coli 50 µg 81072 $405 Buy Now
Recombinant Mononucleosomes (H2A.Z) - biotinylated E. coli 20 µg 31583 $435 Buy Now
Recombinant Mononucleosomes (TH2B) - biotinylated E. coli 20 µg 31557 $435 Buy Now
Recombinant Mononucleosomes H3R2/8/17 citrul (EPL) E. coli 20 µg 81165 $425 Buy Now
1 mg 81865 $6,225 Buy Now
Recombinant Mononucleosomes H3R2/8/17 citrul (EPL) - biotin E. coli 20 µg 81166 $450 Buy Now
1 mg 81866 $6,675 Buy Now
Recombinant Mononucleosomes H3T3ph (EPL) E. coli 20 µg 81161 $415 Buy Now
1 mg 81861 $6,225 Buy Now
Recombinant Mononucleosomes H3T3ph (EPL) - biotin E. coli 20 µg 81162 $445 Buy Now
1 mg 81862 $6,675 Buy Now
Recombinant Mononucleosomes H3K4me1 (EPL) - biotinylated E. coli 20 µg 31585 $445 Buy Now
Recombinant Mononucleosomes H3K4me1/H3K27ac - biotin E. coli / Synthetic 10 µg 81003 $415 Buy Now
Recombinant Mononucleosomes H3K4me2 (EPL) E. coli 20 µg 81073 $415 Buy Now
Recombinant Mononucleosomes H3K4me2 (EPL) - biotin E. coli 20 µg 81074 $445 Buy Now
Recombinant Mononucleosomes H3K4me3 (EPL) - biotinylated E. coli 20 µg 31584 $445 Buy Now
Recombinant Mononucleosomes H3K4me3/H3K27ac - biotin E. coli / Synthetic 10 µg 81004 $415 Buy Now
Recombinant Mononucleosomes H3K4me3/H3K27me3 - biotin E. coli / Synthetic 10 µg 81005 $415 Buy Now
Recombinant Mononucleosomes H3K9ac (EPL) E. coli 20 µg 81075 $415 Buy Now
Recombinant Mononucleosomes H3K9ac (EPL) - biotin E. coli 20 µg 81018 $455 Buy Now
Recombinant Mononucleosomes H3K9me3 (EPL) E. coli 20 µg 31586 $425 Buy Now
Recombinant Mononucleosomes H3K9me3 (EPL) - biotinylated E. coli 20 µg 31555 $455 Buy Now
Recombinant Mononucleosomes H3S10ph (EPL) E. coli 20 µg 81163 $415 Buy Now
1 mg 81863 $6,225 Buy Now
Recombinant Mononucleosomes H3S10ph (EPL) - biotin E. coli 20 µg 81164 $445 Buy Now
1 mg 81864 $6,675 Buy Now
Recombinant Mononucleosomes H3K14ac (EPL) - biotin E. coli 20 µg 81001 $455 Buy Now
Recombinant Mononucleosomes H3K27ac E. coli / Synthetic 10 µg 81077 $405 Buy Now
Recombinant Mononucleosomes H3K27ac - biotin E. coli / Synthetic 10 µg 81002 $410 Buy Now
Recombinant Mononucleosomes H3K27me3 (MLA) E. coli 20 µg 81134 $400 Buy Now
1 mg 81834 $4,450 Buy Now
Recombinant Mononucleosomes H3K27me3 (MLA) - biotin E. coli 20 µg 81135 $420 Buy Now
1 mg 81835 $5,190 Buy Now
Recombinant Mononucleosomes H3K36me3 (MLA) E. coli 20 µg 81116 $400 Buy Now
1 mg 81816 $4,450 Buy Now
Recombinant Mononucleosomes H3K36me3 (MLA) - biotin E. coli 20 µg 81076 $420 Buy Now
1 mg 81776 $5,200 Buy Now
Recombinant Mononucleosomes H3K79me1 (MLA) E. coli 20 µg 81136 $400 Buy Now
Recombinant Mononucleosomes H3K79me1 (MLA) - biotin E. coli 20 µg 81137 $420 Buy Now
Recombinant Mononucleosomes H3K79me2 (MLA) E. coli 20 µg 81138 $400 Buy Now
Recombinant Mononucleosomes H3K79me2 (MLA) - biotin E. coli 20 µg 81139 $420 Buy Now
Recombinant Mononucleosomes H3K79me3 (MLA) E. coli 20 µg 81140 $400 Buy Now
Recombinant Mononucleosomes H3K79me3 (MLA) - biotin E. coli 20 µg 81141 $420 Buy Now
Recombinant Mononucleosomes (H3.1) E. coli 50 µg 81070 $405 Buy Now
1 mg 81770 $4,000 Buy Now
Recombinant Mononucleosomes (H3.1) - biotinylated E. coli 20 µg 31467 $410 Buy Now
Recombinant Mononucleosomes (H3.3) E. coli 50 µg 81071 $405 Buy Now
1 mg 81771 $4,000 Buy Now
Recombinant Mononucleosomes (H3.3) - biotinylated E. coli 20 µg 31469 $410 Buy Now
Recombinant Mononucleosomes H3.3 (K27M) - biotin E. coli 20 µg 81006 $435 Buy Now
Recombinant Mononucleosomes H3.3 (G34L) - biotin E. coli 20 µg 81008 $435 Buy Now
Recombinant Mononucleosomes H3.3 (G34R) - biotin E. coli 20 µg 81009 $435 Buy Now
Recombinant Mononucleosomes H3.3 (G34V) - biotin E. coli 20 µg 81010 $435 Buy Now
Recombinant Mononucleosomes H3.3 (G34W) - biotin E. coli 20 µg 81011 $435 Buy Now
Recombinant Mononucleosomes H3.3 (K36M) - biotin E. coli 20 µg 81007 $435 Buy Now
Recombinant Mononucleosomes H4K20me3 (MLA) E. coli 20 µg 81080 $400 Buy Now
Recombinant Mononucleosomes H4K20me3 (MLA) - biotin E. coli 20 µg 81081 $420 Buy Now
1 mg 81781 $5,200 Buy Now
Recombinant Polynucleosomes (H3.1) E. coli 20 µg 31466 $410 Buy Now
Recombinant Polynucleosomes (H3.3) E. coli 20 µg 31468 $410 Buy Now
1 mg 31868 $3,950 Buy Now
Recombinant Polynucleosomes H3.3 (K27M) E. coli 20 µg 31562 $410 Buy Now
Recombinant Polynucleosomes H3.3 (G34L) E. coli 20 µg 31558 $410 Buy Now
1 mg 31958 $3,950 Buy Now
Recombinant Polynucleosomes H3.3 (G34R) E. coli 20 µg 31559 $410 Buy Now
Recombinant Polynucleosomes H3.3 (G34V) E. coli 20 µg 31560 $410 Buy Now
Recombinant Polynucleosomes H3.3 (G34W) E. coli 20 µg 31561 $410 Buy Now
1 mg 31961 $3,950 Buy Now
Recombinant Polynucleosomes H3.3 (K36M) E. coli 20 µg 31563 $410 Buy Now
1 mg 31963 $3,950 Buy Now