Recombinant PRDM6 protein

Aliases: PFM3
Catalog No: 31495 Format: 20 µg $410 Buy
Expressed In: Baculovirus Protein Species: Human

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Contents

Full length recombinant PRDM6 protein was expressed in Sf9 cells and is supplied in 25 mM Hepes pH 7.5, 300 mM NaCl, 5% Glycerol, 0.04% Triton X-100, 0.2 mM TCEP. Please refer to product insert upon arrival for lot-specific concentration.

Background

PRDM6 (PR Domain Containing 6) is a putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. PRDM6 can regulate the phenotypic plasticity of smooth muscle cells by suppressing differentiation and maintaining the proliferative potential of vascular SMCs. It also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation.

Application Notes

This product was manufactured as described in Protein Details. Where possible, Active Motif has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data for a given product is shown on the lot-specific Technical Data Sheet.

Protein Details

Recombinant PRDM6 protein (accession number NP_001129711.1) was expressed in Sf9 cells and contains an N-terminal FLAG-Tag with a molecular weight of 64.4 kDa. The recombinant protein is >75% pure by SDS-PAGE.

 
PRDM6 protein Coomassie gel

Recombinant PRDM6 protein gel.
Recombinant PRDM6 run on an 8% SDS-PAGE gel and stained with Coomassie blue.

Storage

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Guarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.